Skip to main content
Shedd Aquarium

Main Street Inn

404 S. Main St., Galena, IL 61036

Vacation Rentals

Located on Galena's historic downtown Main Street, the Main Street Inn is a cozy, inviting place to relax that is listed on the National Register of Historic Places (circa 1850).

Main Street Inn offers 6 luxurious and spacious rooms located on the 2nd floor that will meet the needs of romantic adventures, friend getaways, or anything in between. Walk out the front door to take a stroll up Main Street and browse through Galena's unique stores and boutiques, enjoy dining at one of Galena's fine restaurants, or stop by one of our wine shops. Or stay in and simply enjoy the comforts of your room.

Whatever your reason for coming to Galena, the Main Street Inn is here for you!

What's happening nearby...

Haunted Galena Conference

DeSoto House Hotel •  Apr 04 – Apr 06 @ 4PM

Embrace the Darkness with Haunted Galena Tour Company at the haunted DeSoto House Hotel!

Read more about Haunted Galena Conference

Kiwanis River Trail Run

Galena River Trail •  Apr 19 @ 10AM

The Kiwanis Club of Galena invites you to sign up for their Annual Run with proceeds benefitting local organizations with supporting children and improving the quality…

Read more about Kiwanis River Trail Run

Julien Dubuque International Film Fest Screenings in Galena

Galena Center for the Arts, DeSoto House Hotel •  Apr 21 – Apr 22 @ 10AM

The Julien Dubuque International Film Festival (JDIFF) begins with the first 2 days in Galena in the Desoto House Hotel and the Galena Center for the Arts

Read more about Julien Dubuque International Film Fest Screenings in Galena

You might also be interested...

CountryView Home

Galena

CountryView Home, located in Galena, Illinois is set in an exquisite natural area surrounded by over 80 acres of beautiful landscapes.

Read more about CountryView Home

The Eagle's Nest

Galena

The Eagle's Nest is a luxurious 12,000-square-foot vacation rental home perfect for corporate events, golf or ski groups, and destination family gatherings.

Read more about The Eagle's Nest

A Great Escape Vacation Rental Homes

Galena

A Great Escape! Vacation Homes of Galena provides beautiful, affordable vacation homes of various sizes in the Galena Territory. The homes are situated near the city…

Read more about A Great Escape Vacation Rental Homes

Subscribe to Our Newsletter

Get inspired by top travel stories, gain access to exclusive promotions and contests, and discover even more reasons to #EnjoyIllinois.